Aging is a chronic, complicated process that leads to degenerative physical and biological changes in living organisms. Aging is associated with permanent, gradual physiological cellular decay that affects all aspects of cellular mechanobiological features, including cellular cytoskeleton structures, mechanosensitive signaling pathways, and forces in the cell, as well as the cell's ability to sense and adapt to extracellular biomechanical signals in the tissue environment through mechanotransduction. These mechanobiological changes in cells are directly or indirectly responsible for dysfunctions and diseases in various organ systems, including the cardiovascular, musculoskeletal, skin, and immune systems. This review critically examines the role of aging in the progressive decline of the mechanobiology occurring in cells, and establishes mechanistic frameworks to understand the mechanobiological effects of aging on disease progression and to develop new strategies for halting and reversing the aging process. Our review also highlights the recent development of novel bioengineering approaches for studying the key mechanobiological mechanisms in aging.

中文翻译：

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衰老的细胞力学生物学：从生物学到力学

衰老是一个慢性、复杂的过程，会导致生物体发生退行性的物理和生物学变化。衰老与永久性的、逐渐的生理性细胞衰变有关，这会影响细胞力学生物学特征的各个方面，包括细胞骨架结构、力学敏感信号通路和细胞中的力，以及细胞感知和适应细胞外生物力学信号的能力。通过机械转导的组织环境。细胞中的这些机械生物学变化直接或间接导致各种器官系统的功能障碍和疾病，包括心血管、肌肉骨骼、皮肤和免疫系统。这篇综述批判性地研究了衰老在细胞中发生的机械生物学逐渐衰退中的作用，并建立机制框架以了解衰老对疾病进展的机械生物学影响，并制定阻止和逆转衰老过程的新策略。我们的综述还强调了用于研究衰老关键机械生物学机制的新型生物工程方法的最新发展。