Abstract Laboratory diagnosis of pathologies caused by virus plays a critical role in outbreak response efforts and establishing safe and expeditious testing strategies. Detection of pathogenic virus using commercial solutions require specific tools and laborious laboratory procedures. This makes the day-to-day on time detection of virus infections the limiting step in any outbreak. The need for new diagnostic tools easily available to poor and rural underdeveloped areas where health infrastructure and trained personnel are scarce is highly desirable. The widely known intrinsic properties of Metal-Organic Frameworks (MOFs) embody them with the potential to overcome some of the challenges inherent to virus detection. MOFs are already components of functional devices capable of perform an uninterrupted detection of molecular targets in real time. In this review, we summarise the few studies concerning the reported MOFs used as sensors for pathogenic virus. We emphasise the structural and physical properties of these materials which can open the possibility for their use in this type of sensors and conclude on how the field can progress to envisage the usage of MOFs by the pharmaceutical industry to develop new sensors for these sub-microscopic infectious agents.

中文翻译：

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病毒遇到金属有机框架：解决世界级问题的纳米多孔解决方案？

摘要 病毒引起的病理学实验室诊断在疫情应对工作和建立安全、快速的检测策略中起着至关重要的作用。使用商业解决方案检测病原病毒需要特定的工具和费力的实验室程序。这使得病毒感染的日常按时检测成为任何爆发中的限制步骤。卫生基础设施和训练有素的人员稀缺的贫困和农村欠发达地区非常需要易于获得的新诊断工具。金属有机框架 (MOF) 广为人知的内在特性使它们具有克服病毒检测固有挑战的潜力。MOF 已经是功能设备的组成部分，能够实时不间断地检测分子目标。在这篇综述中，我们总结了有关报道的用作病原病毒传感器的 MOF 的少数研究。我们强调这些材料的结构和物理特性，这可以为它们在此类传感器中的使用开辟可能性，并总结该领域如何发展以设想制药行业使用 MOF 为这些亚显微传感器开发新的传感器。传染因子。