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Actin dynamics during tumor cell dissemination
International Review of Cell and Molecular Biology ( IF 6.420 ) Pub Date : 2020-11-24 , DOI: 10.1016/bs.ircmb.2020.09.004
Chandrani Mondal 1 , Julie S Di Martino 1 , Jose Javier Bravo-Cordero 1
Affiliation  

The actin cytoskeleton is a dynamic network that regulates cellular behavior from development to disease. By rearranging the actin cytoskeleton, cells are capable of migrating and invading during developmental processes; however, many of these cellular properties are hijacked by cancer cells to escape primary tumors and disseminate to distant organs in the body. In this review article, we highlight recent work describing how cancer cells regulate the actin cytoskeleton to achieve efficient invasion and metastatic colonization. We also review new imaging technologies that are capable of revealing the complex architecture and regulation of the actin cytoskeleton during motility and invasion of tumor cells.



中文翻译:

肿瘤细胞传播过程中的肌动蛋白动力学

肌动蛋白细胞骨架是一个动态网络,可调节从发育到疾病的细胞行为。通过重新排列肌动蛋白细胞骨架,细胞能够在发育过程中迁移和入侵;然而,许多这些细胞特性被癌细胞劫持以逃避原发性肿瘤并传播到体内的远处器官。在这篇综述文章中,我们重点介绍了最近描述癌细胞如何调节肌动蛋白细胞骨架以实现有效侵袭和转移定植的工作。我们还回顾了能够揭示在肿瘤细胞运动和侵袭过程中肌动蛋白细胞骨架的复杂结构和调节的新成像技术。

更新日期:2020-11-24
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