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Fluorinated dendritic Silicon (IV) Phthalocyanines Nanoparticles: Synthesis, Photoinduced intramolecular Energy Transfer and DNA interaction
Dyes and Pigments ( IF 4.5 ) Pub Date : 2020-11-24 , DOI: 10.1016/j.dyepig.2020.109013
Wenling Xiao , Xinqiao Guan , Bingcheng Huang , Qiuhao Ye , Tiantian Zhang , Kuizhi Chen , Yiru Peng , Fangmeng Fu

Two series of fluorinated and non-fluorinated dendritic silicon (IV) phthalocyanines with cyano/nitro/ester terminal functionalities have been synthesized. Their structures were characterized by elemental analysis, FT-IR, 1H NMR and ESI-MS. The effects of fluorinated groups and terminal functionalities properties on the photophysical properties, photoinduced intermolecular electron transfer and intramolecular energy transfer of silicon phthalocyanines were compared. In order to endow water soluble and biocompatibility to these silicon phthalocyanines, amphiphilic diblock copolymer polyethylene glycol monomethyl ether–polycaprolactone was used to encapsulate these silicon phthalocyanines to form fluorinated and non-fluorinated dendritic silicon phthalocyanines nanoparticles. The binding model between the fluorinated dendritic silicon phthalocyanines nanoparticles and calf thymus DNA was studied by UV-Vis and fluorescence spectroscopic method. The photocleavage DNA activities of three fluorinated dendritic silicon phthalocyanines nanoparticles were compared and the possible cleavage mechanism was proposed.



中文翻译:

氟化树枝状硅(IV)酞菁纳米粒子:合成,光诱导的分子内能量转移和DNA相互作用

已经合成了具有氰基/硝基/酯末端官能团的两个系列的氟化和非氟化树枝状硅(IV)酞菁。其结构通过元素分析,FT-IR,11 H NMR和ESI-MS。比较了氟化基团和末端官能团性质对硅酞菁的光物理性质,光诱导的分子间电子转移和分子内能量转移的影响。为了赋予这些硅酞菁水溶性和生物相容性,两亲性二嵌段共聚物聚乙二醇单甲醚-聚己内酯被用于封装这些硅酞菁,以形成氟化和非氟化的树枝状硅酞菁纳米粒子。通过紫外-可见光谱和荧光光谱研究了氟化树枝状硅酞菁纳米粒子与小牛胸腺DNA的结合模型。

更新日期:2020-11-25
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