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Mechanobiology of the Mitotic Spindle
Developmental Cell ( IF 11.8 ) Pub Date : 2020-11-24 , DOI: 10.1016/j.devcel.2020.11.003
Nenad Pavin , Iva M. Tolić

The mitotic spindle is a microtubule-based assembly that separates the chromosomes during cell division. As the spindle is basically a mechanical micro machine, the understanding of its functioning is constantly motivating the development of experimental approaches based on mechanical perturbations, which are complementary to and work together with the classical genetics and biochemistry methods. Recent data emerging from these approaches in combination with theoretical modeling led to novel ideas and significant revisions of the basic concepts in the field. In this Perspective, we discuss the advances in the understanding of spindle mechanics, focusing on microtubule forces that control chromosome movements.



中文翻译:

有丝分裂纺锤体的力学生物学

有丝分裂纺锤体是基于微管的组件,在细胞分裂过程中将染色体分开。由于主轴基本上是一台机械微型机器,因此对其功能的理解不断激发着基于机械扰动的实验方法的发展,这些方法是对经典遗传学和生物化学方法的补充和配合。这些方法与理论建模相结合得出的最新数据导致了该领域的基本概念的新颖思想和重大修改。在本《观点》中,我们将讨论对纺锤体力学的理解,重点是控制染色体运动的微管力。

更新日期:2021-01-25
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