An unprecedented worldwide spread of the SARS-CoV-2 has imposed severe challenges on healthcare facilities and medical infrastructure. The global research community faces urgent calls for the development of rapid diagnostic tools, effective treatment protocols, and most importantly, vaccines against the pathogen. Pooling together expertise across broad domains to innovate effective solutions is the need of the hour. With these requirements in mind, in this review, we provide detailed critical accounts on the leading efforts at developing diagnostics tools, therapeutic agents, and vaccine candidates. Importantly, we furnish the reader with a multidisciplinary perspective on how conventional methods like serology and RT-PCR, as well as cutting-edge technologies like CRISPR/Cas and artificial intelligence/machine learning, are being employed to inform and guide such investigations. We expect this narrative to serve a broad audience of both active and aspiring researchers in the field of biomedical sciences and engineering and help inspire radical new approaches towards effective detection, treatment, and prevention of this global pandemic.

中文翻译：

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COVID-19：诊断工具、治疗策略和疫苗开发的进展

SARS-CoV-2 史无前例的全球传播给医疗保健设施和医疗基础设施带来了严峻挑战。全球研究界迫切需要开发快速诊断工具、有效的治疗方案，最重要的是开发针对病原体的疫苗。汇集广泛领域的专业知识以创新有效的解决方案是当下的需要。考虑到这些要求，在本次审查中，我们详细介绍了在开发诊断工具、治疗剂和候选疫苗方面的主要努力。重要的是，我们为读者提供了多学科视角，了解血清学和 RT-PCR 等传统方法，以及 CRISPR/Cas 和人工智能/机器学习等尖端技术，正在受雇为此类调查提供信息和指导。我们希望这种叙述能够为生物医学科学和工程领域活跃和有抱负的研究人员的广泛受众提供服务，并有助于激发有效检测、治疗和预防这一全球流行病的全新方法。