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Nanoemulsions of essential oils to improve solubility, stability and permeability: a review
Environmental Chemistry Letters ( IF 15.7 ) Pub Date : 2020-11-23 , DOI: 10.1007/s10311-020-01142-2
Thaís Nogueira Barradas , Kattya Gyselle de Holanda e Silva

There is a growing society demand for healthier, safer and environmental-friendly products. For instance, essential oils are emerging as a natural alternatives for replacing synthetic pharmaceuticals. Essential oils have indeed proven in vitro pharmacological activities to treat various diseases. Nonetheless, the application of essential oils is limited by their low solubility, low bioavailability, low permeability, uncontrolled volatility and low long-term stability. These issues can be solved by encapsulation of essential oils in nanoemulsions. Nanoemulsions display unique properties such as nanometric size, increased surface area and stability, which increase the efficiency of pharmaceutical dosage. Here we review nanoemulsion formulations, types of surfactants and oils, and their applications for essential oils encapsulation. We present methods to produce nanoemulsions such as high-pressure homogenization, microfluidizers, ultrasonic homogenization, phase inversion composition and phase inversion temperature. We also discuss nanoemulsion instability.



中文翻译:

精油的纳米乳液可改善溶解性,稳定性和渗透性:综述

社会上对健康,安全和环保产品的需求不断增长。例如,精油作为替代合成药物的天然替代品正在出现。精油确实已经证明可以治疗各种疾病的体外药理活性。但是,精油的应用受到其低溶解度,低生物利用度,低渗透性,不受控制的挥发性和低长期稳定性的限制。这些问题可以通过将精油包封在纳米乳液中来解决。纳米乳剂具有独特的性能,例如纳米尺寸,增加的表面积和稳定性,从而提高了药物剂量的效率。在这里,我们回顾了纳米乳液配方,表面活性剂和油的类型及其在香精油封装中的应用。我们介绍了生产纳米乳液的方法,例如高压均质,微流化器,超声均质,相转化组成和相转化温度。我们还讨论了纳米乳液的不稳定性。

更新日期:2020-11-25
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