Use of sanitizers in diagnostic centres causes derangement in quality control values of lipase and triglycerides (TG) analytes during COVID-19. Our study provides a practical insight into the type of sanitizers to be used in a laboratory. Performance Verifier (PV) and reagents (lipase and TG) were contaminated with sanitizer and 70% isopropyl alcohol. Groups formed were- PVNet (G1), PV with Sanitizer (G2), PV with 70% Alcohol (G3), Sanitizer contaminated reagent (G4). Controls PV-1 and PV-2 were run. ANOVA and Tukey’s test among groups and between groups were compared. Significant difference in mean PV-1and PV-2 values of TG [PV-1, PV-2 (P <0.0001)] and lipase TG [PV-1 P <0.0001) PV-2 P <0.001] among all tested groups were observed. Between-group analysis showed significantly higher PV-1 and PV-2 values in sanitizer contaminated PV group (P <0.001) compared to Neat PVs (P <0.001), and PVs contaminated with 70% alcohol (P <0.001). sanitizer contaminated PV-1 values were significantly higher when compared to Neat PV-1 (P <0.001)for lipase. It is advised that isopropyl alcohol (70%) should be preferred over glycerol containing sanitizers to reduce pre-analytical errors for lipase and TG estimation.

中文翻译：

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临床实验室中消毒剂对脂肪酶和甘油三酸酯分析物质量的影响

在诊断中心使用消毒剂会导致COVID-19期间脂肪酶和甘油三酸酯（TG）分析物的质量控制值出现偏差。我们的研究为在实验室中使用的消毒剂类型提供了实用的见解。Performance Verifier（PV）和试剂（脂肪酶和TG）已被消毒剂和70％异丙醇污染。形成的组为-PVNet（G1），带消毒剂的PV（G2），带70％酒精的PV（G3），被消毒剂污染的试剂（G4）。运行对照PV-1和PV-2。比较组间和组间的方差分析和Tukey检验。TG [PV-1，PV-2（P <0.0001）]和脂肪酶TG [PV-1 P <0.0001）PV-2 P的平均PV-1和PV-2值有显着差异在所有测试组中观察到的<0.001。组间分析在卫生洗涤剂污染PV组显著显示较高的PV-1和PV-2的值（P <0.001）相比，纯的PV（P污染用70％酒精（<0.001），和PV P <0.001）。与脂肪酶的Neat PV-1相比，消毒剂污染的PV-1值明显更高（P <0.001）。建议使用异丙醇（70％）优于含甘油的消毒剂，以减少脂肪酶和TG估算的分析前误差。