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Shape of population interfaces as an indicator of mutational instability in coexisting cell populations
Physical Biology ( IF 2 ) Pub Date : 2020-11-19 , DOI: 10.1088/1478-3975/abb2dd
Clarisa E Castillo 1 , Maxim O Lavrentovich 1
Affiliation  

Cellular populations such as avascular tumors and microbial biofilms may ‘invade’ or grow into surrounding populations. The invading population is often comprised of a heterogeneous mixture of cells with varying growth rates. The population may also exhibit mutational instabilities, such as a heavy deleterious mutation load in a cancerous growth. We study the dynamics of a heterogeneous, mutating population competing with a surrounding homogeneous population, as one might find in a cancerous invasion of healthy tissue. We find that the shape of the population interface serves as an indicator for the evolutionary dynamics within the heterogeneous population. In particular, invasion front undulations become enhanced when the invading population is near a mutational meltdown transition or when the surrounding ‘bystander’ population is barely able to reinvade the mutating population. We characterize these interface undulations and the effective fitness of the heterogeneous population in one- and two-dimensional systems.



中文翻译:

群体界面的形状作为共存细胞群体突变不稳定性的指标

无血管肿瘤和微生物生物膜等细胞群可能“侵入”或生长到周围的群中。入侵种群通常由具有不同生长速率的细胞的异质混合物组成。种群还可能表现出突变的不稳定性,例如癌性生长中的大量有害突变负荷。我们研究了一个异质的、变异的种群与周围的同质种群竞争的动态,正如人们可能在健康组织的癌性入侵中发现的那样。我们发现种群界面的形状可以作为内部进化动态的指标异质的人口。特别是,当入侵种群接近突变崩溃过渡或当周围的“旁观者”种群几乎无法重新入侵突变种群时,入侵前沿波动会增强。我们描述了这些界面波动和异质种群在一维和二维系统中的有效适应度。

更新日期:2020-11-19
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