Abstract: Sepsis is life-threatening organ dysfunction caused by an imbalance in the body’s response to infection and acute lung injury (ALI) related to sepsis is a common complication. The rapid morbidity and high mortality associated with sepsis is a significant clinical problem facing critical care medicine. Inflammation plays a vital role in the occurrence of sepsis. Notably, the body produces different immune cells and pro-inflammatory factors to clear pathogens. However, excessive inflammation can damage multiple tissues and organs when it fails to resolve in time. Additionally, lymphatic vessels could effectively transfer inflammatory cells and factors away from tissues and into blood circulation, thereby reducing damage, and promoting the resolution of inflammation. Therefore, any dysfunction and/or destruction of the lymphatic system may result in lymphedema followed by inflammatory storms and eventual sepsis. Consequently, the present study aimed to review and highlight the role of lymphatic vessels in related body tissues and organs during sepsis and other associated diseases.

Keywords: sepsis, acute lung injury, lymphatic flow


中文翻译：

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淋巴血流：脓毒症相关急性肺损伤的潜在目标。

摘要：败血症是由人体对感染的反应不平衡引起的威胁生命的器官功能障碍，与败血症有关的急性肺损伤（ALI）是常见的并发症。与败血症相关的快速发病率和高死亡率是重症监护医学面临的重大临床问题。炎症在败血症的发生中起着至关重要的作用。值得注意的是，人体产生不同的免疫细胞和促炎因子来清除病原体。但是，过度的炎症如果未能及时解决，可能会损害多个组织和器官。另外，淋巴管可以有效地将炎性细胞和因子从组织转移到血液循环中，从而减少损伤并促进炎症的消退。因此，淋巴系统的任何功能障碍和/或破坏都可能导致淋巴水肿，继而引起炎症性风暴和最终的败血症。因此，本研究旨在回顾和强调脓毒症和其他相关疾病期间淋巴管在相关身体组织和器官中的作用。

关键词：败血症，急性肺损伤，淋巴流