The first total synthesis of four naturally occurring dihydro-β-agarofuran esters has been accomplished via a highly stereocontrolled 14-step access to their common core triol, (−)-isocelorbicol. A semipinacol rearrangement of an epoxy alcohol to install a quaternary carbon, diastereoselective conjugate reduction of a spirocyclic butenolide for the establishment of a methyl-bearing chiral center, and ring-closing metathesis to construct the decalin ring system were exploited as the key steps for the high-yielding synthesis of (−)-isocelorbicol.

中文翻译：

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立体控制的（-）-异氟比索的全合成及其对天然二氢-β-agarofuran酯的修饰

四种天然存在的二氢-β-琼脂呋喃酯的第一个全合成反应是通过高度立体控制的14步进入其常见的核心三醇（-）-异celicbicol。环氧醇的半频醇重排以安装季碳，螺环丁烯内酯的非对映选择性共轭还原以建立带有甲基的手性中心，以及闭环易位来构造十氢化萘环体系。 （-）-异青霉酚的高产率合成。