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Synthesis and Performance of Hybrid Hydrogels Loaded with Methylene Blue and Its Use for Antimicrobial Photodynamic Inactivation
Journal of Chemistry ( IF 3 ) Pub Date : 2020-11-21 , DOI: 10.1155/2020/6679960
Oksana Nadtoka 1 , Pavlo Virych 1 , Serhiy Nadtoka 1 , Nataliya Kutsevol 1
Affiliation  

Development and characterization of hybrid hydrogels loaded with methylene blue, which are designed to apply for photodynamic therapy, are presented. Hybrid hydrogels were synthesized by grafting polyacrylamide onto dextran/dextran sulfate sodium salt using N, N′-methylene-bis-acrylamide as a cross-linker. The differences in microstructure of synthesized hydrogels were proved by scanning electron microscopy. FTIR spectra testify that the chemical nature of hydrogel components affects the hydrogel hydrophilicity. The swelling properties of hydrogels in water and absorption/desorption hydrogels’ ability towards methylene blue were studied. It was shown that dye sorption was dependent on the hydrogel type. The hydrogel based on dextran and polyacrylamide revealed the highest ability to release absorbed dye. The bactericidal effect of this hydrogel loaded with methylene blue and activated by red light in suspension and solid medium of S. aureus was tested. The increase of bactericidal activity of hybrid hydrogel was dependent on radiation doses.

中文翻译:

载有亚甲蓝的混合水凝胶的合成和性能及其在抗菌光动力灭活中的应用

介绍了载有亚甲蓝的混合水凝胶的开发和表征,这些水凝胶旨在应用于光动力疗法。通过使用 N, N'-亚甲基-双-丙烯酰胺作为交联剂将聚丙烯酰胺接枝到葡聚糖/葡聚糖硫酸钠盐上来合成混合水凝胶。通过扫描电子显微镜证明了合成水凝胶微观结构的差异。FTIR 光谱证明水凝胶组分的化学性质会影响水凝胶的亲水性。研究了水凝胶在水中的溶胀特性和吸收/解吸水凝胶对亚甲蓝的能力。结果表明,染料吸附取决于水凝胶类型。基于葡聚糖和聚丙烯酰胺的水凝胶显示出释放吸收染料的最高能力。测试了这种载有亚甲蓝并被红光激活的水凝胶在金黄色葡萄球菌的悬浮液和固体介质中的杀菌效果。混合水凝胶杀菌活性的增加取决于辐射剂量。
更新日期:2020-11-21
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