Despite the strong evidence on the cardiac and renal damages after chronic exposure to cigarette smoke, there is a paucity of data on its short-term effects. The study evaluated the short-term effects of cigarette smoking on left ventricular (LV) remodeling, in vitro myocardial and renal function. Female Wistar rats were randomized to control (C) and cigarette smoking rats for eight weeks. Physical capacity was assessed using an adapted model of exhaustive swim; left ventricle (LV) morphology and function were also evaluated. Renal function was assessed by creatinine clearance and urine protein. The in vitro myocardial performance was analyzed in isolated papillary muscles. Rats exhibited reduced physical capacity after short-term cigarette smoking. Although there was no change on LV function, reduced chamber diameter was found in the smoking group associated with an increased LV wall thickness. There was augmented cardiac mass compared to C that was confirmed by increased cardiomyocyte nucleus volume, but in vitro myocardial performance and renal function were unchanged. A short-term cigarette smoking induces cardiac remodeling without abnormalities in function. The smoking group still preserved renal function and in vitro myocardial performance. However, the reduced physical capacity may suggest an impairment of the cardiac reserve.

中文翻译：

---

大鼠短期吸烟会削弱身体能力并引起心脏重塑

尽管有强有力的证据表明长期接触香烟烟雾会损害心脏和肾脏，但目前尚缺乏有关其短期影响的数据。该研究评估了吸烟对左心室重构，体外心肌和肾脏功能的短期影响。将雌性Wistar大鼠随机分为对照组（C）和吸烟大鼠八周。使用适应性的力竭游泳模型评估体能；还评估了左心室（LV）的形态和功能。通过肌酐清除率和尿蛋白评估肾功能。在体外分析离体乳头肌的心肌表现。短期吸烟后大鼠的身体活动能力下降。尽管左室功能没有改变，但吸烟组发现室直径减小与左室壁厚度增加有关。心肌细胞核体积增加证实，与C相比，心脏质量增加，但体外心肌性能和肾功能未改变。短期吸烟会导致心脏重塑，而不会出现功能异常。吸烟组仍保留肾功能和体外心肌功能。但是，体力下降可能提示心脏储备受损。