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Evaluation of Colostral Immunity Against Equine Herpesvirus Type 1 (EHV-1) in Martina Franca's Foals
Frontiers in Veterinary Science ( IF 3.2 ) Pub Date : 2020-10-05 , DOI: 10.3389/fvets.2020.579371
Cristina E. Di Francesco , Camilla Smoglica , Ippolito De Amicis , Federica Cafini , Augusto Carluccio , Alberto Contri

Eight Martina Franca pregnant jennies were selected in order to evaluate the transfer of colostral antibodies against equine herpesvirus type 1 in their relative foals after immunization with a commercial inactivated vaccine, compared with an unvaccinated group. Samples of serum and colostrums/milk were collected from jennies and foals under study starting from 10 min before and up to 21 days after the foaling. Specific anti-EHV-1 antibody titers were evaluated by means of a serum neutralization test, and the results obtained from both groups were analyzed. The serological titers in the vaccinated jennies was significantly higher (p < 0.01). No significant differences were found in the specific time-point intervals in both groups examined (p > 0.05). The antibody titers in milk at the time of delivery and subsequent withdrawal (T0 and T1) were very high in both groups, but no significant differences were found between the two groups (p > 0.05). In the foal sera, a significant difference was found between foals in the vaccinated group compared with those in the unvaccinated group (p < 0.05). Finally, a significant correlation (p < 0.05) was observed between the antibody titers found in serum and colostrum of jennies and the foal titers in the first time-point sampling (up to 12 h after foaling). The results confirm a substantial homology in the antibody production compared with other most investigated equids, highlighting the efficacy of the vaccination against EHV-1 of the jennies to ensure the protective immunity to their foals during the first weeks after delivery.



中文翻译:

马蒂娜·弗朗卡的马驹对马1型疱疹病毒(EHV-1)的巨结肠免疫力的评估。

与未接种疫苗的组相比,选择了八只马丁纳·弗兰卡怀孕的詹妮,以评估在用商业灭活疫苗免疫后,相对马驹中针对马1型疱疹病毒的初抗体的转移。从研究的珍妮和小马驹中收集血清和初乳/牛奶样品,从小马驹前的10分钟开始,直到小马驹后的21天。通过血清中和试验评估特异性抗EHV-1抗体的效价,并分析从两组获得的结果。疫苗接种的珍妮中的血清滴度明显更高(p<0.01)。在检查的两组中,特定时间点间隔均无显着差异(p> 0.05)。两组在分娩和随后停药时牛奶中的抗体滴度都很高,但两组之间没有发现显着差异(p> 0.05)。在小马血清中,接种后的小马与未接种小马的小马之间存在显着差异(p<0.05)。最后,显着的相关性(p在詹妮犬的血清和初乳中发现的抗体效价与第一次时间点采样(驹后最多12小时)的驹效价之间发现<0.05。结果证实,与其他大多数被调查的同类产品相比,抗体生产具有实质同源性,突出了针对珍妮的EHV-1疫苗接种的有效性,以确保在分娩后的最初几周内对它们的驹具有保护性免疫力。

更新日期:2020-11-23
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