Vaccination of goats against tuberculosis (TB) has been promoted as an ancillary tool for controlling the disease in infected livestock herds. A three-year trial to assess the efficacy of BCG vaccine was carried out in five goat herds. At the beginning of the trial (month 0), all animals were tested for TB using thee different diagnostic tests. Animals negative to all tests were vaccinated with BCG and all replacement goat kids were also systematically vaccinated throughout the trial. All animals were tested by Interferon-gamma release assay (IGRA) using vaccine compatible reagents at months 6, 12, 24, and 36. The risk factors for TB infection were also evaluated. At the end of the study, four out of five farms showed variable reductions of the initial prevalence (93.5%, 28.5%, 23.2%, and 14.3% respectively), and an overall incidence reduction of 50% was observed in BCG vaccinated goats, although adult vaccinated goats showed higher incidences than vaccinated goat kids. The unvaccinated positive animals remaining in herds and adult BCG vaccinated goats significantly enhanced the risk of infection in vaccinated animals. A systematic vaccination of goats with BCG, together with the removal of positive unvaccinated animals, may contribute to reducing the TB prevalence in goat herds.

山羊已经接种了结核病疫苗，作为控制感染牲畜群疾病的辅助工具。在五只山羊群中进行了为期三年的评估BCG疫苗功效的试验。在试验开始时（第0个月），使用不同的诊断测试对所有动物的结核病进行了测试。对所有测试均阴性的动物均接种了BCG疫苗，并且在整个试验过程中还对所有替代山羊羔的孩子进行了系统性疫苗接种。在第6、12、24和36个月使用疫苗兼容试剂，通过干扰素-γ释放试验（IGRA）对所有动物进行了测试。还评估了结核感染的危险因素。在研究结束时，五分之四的农场显示出不同程度的初始流行率降低（分别为93.5％，28.5％，23.2％和14.3％），尽管接种成人卡介苗的山羊的患病率要高于接受免疫接种的山羊儿童，但接种卡介苗的山羊的总体发病率降低了50％。牛群和成年卡介苗接种山羊中未接种的阳性动物显着增加了接种动物的感染风险。用BCG对山羊进行系统性疫苗接种，以及清除未接种疫苗的阳性动物，可能有助于降低山羊群的结核病患病率。