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Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota
Scientific Reports ( IF 4.6 ) Pub Date : 2020-11-23 , DOI: 10.1038/s41598-020-77313-6
Florencia Correa-Fiz , Carlos Neila-Ibáñez , Sergio López-Soria , Sebastian Napp , Blanca Martinez , Laia Sobrevia , Simon Tibble , Virginia Aragon , Lourdes Migura-Garcia

Medicated feed is a common strategy to control the occurrence of Streptococcus suis disease in swine production, but feed additives may constitute an alternative to metaphylaxis. In a farm with post-weaning S. suis disease, the following additives were tested: lysozyme (Lys), medium chain fatty acids plus lysozyme (FA + Lys), FA plus a natural anti-inflammatory (FA + antiinf) and amoxicillin (Amox). During the course of the study, FA + antiinf and Amox groups showed lower prevalence of clinical signs compatible with S. suis disease than the rest of the groups. Piglets from the FA + antiinf group showed high diversity and richness in their nasal and faecal microbiota. Diet supplements did not have major effects on the faecal microbiota, where the genus Mitsuokella was the only differentially present in the FA + Lys group. In the nasal microbiota, piglets from FA + antiinf presented higher differential abundance of a sequence variant from Ruminococcaceae and lower abundance of an unclassified genus from Weeksellaceae. In general, we detected more significant changes in the nasal than in the feacal microbiota, and found that parity of the dams affected the microbiota composition of their offspring, with piglets born to gilts exhibiting lower richness and diversity. Our results suggest that additives could be useful to control post-weaning disease when removing antimicrobials in farms.



中文翻译:

饲料添加剂用于控制断奶后猪链球菌病及其对粪便和鼻微生物群的影响

药物饲料是控制猪生产中猪链球菌病发生的常见策略,但饲料添加剂可能构成了替代药物。在断奶后猪链球菌病的农场中,测试了以下添加剂:溶菌酶(Lys),中链脂肪酸加溶菌酶(FA + Lys),FA加上天然抗炎剂(FA + antiinf)和阿莫西林( Amox)。在研究过程中,FA +抗感染药和Amox组显示出与猪链球菌相容的临床体征的患病率低于其余组。FA +抗感染组的仔猪的鼻和粪便微生物群表现出高度的多样性和丰富性。膳食补充剂对粪便微生物菌群没有重大影响,Mitsuokella是FA + Lys组中唯一存在的差异。在鼻微生物群,从FA +仔猪antiinf呈现从一个序列变体的高丰度差Ruminococcaceae和丰度从非保密属低Weeksellaceae。一般而言,我们发现鼻部的变化比粪便微生物区系更为显着,并发现水坝的平价影响了其后代的微生物区系组成,后备母猪的仔猪表现出较低的丰富度和多样性。我们的结果表明,在农场去除抗生素时,添加剂可能对控制断奶后疾病有用。

更新日期:2020-11-23
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