Periodontitis is an infectious, inflammatory disease that is associated with a complex interplay between specific bacteria, host response, and environmental factors. Because of its high degree of familial aggregation, specifically for the more aggressive forms of the disease, genetics factors have been implicated in disease pathogenesis for several decades. This review provides an overview of what we currently know regarding the genetic and epigenetic contributions to periodontal disease and discusses future opportunities in the field.

中文翻译：

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牙周健康和疾病：遗传学的贡献

牙周炎是一种传染性炎症性疾病，与特定细菌、宿主反应和环境因素之间的复杂相互作用有关。由于其高度的家族聚集性，特别是对于更具侵袭性的疾病形式，几十年来，遗传因素一直与疾病发病机制有关。这篇综述概述了我们目前对牙周病的遗传和表观遗传贡献的了解，并讨论了该领域的未来机会。