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Regenerating Hair in Prevascularized Tissue Space Formed by a Controllable Foreign Body Reaction
Advanced Functional Materials ( IF 19.0 ) Pub Date : 2020-11-23 , DOI: 10.1002/adfm.202007483
Lunan Yang 1, 2 , Yong Miao 1 , Yuqing Liu 2 , Shiyi Chen 2 , Yuxin Chen 1 , Weiwen Liu 1 , Jin Wang 1 , Wen Zhong 3 , Quan Wang 4, 5 , Zhiqi Hu 1 , Malcolm Xing 2
Affiliation  

Intracutaneous transplantation of trichogenic cells is a currently endorsed strategy to realize hair regeneration in vivo. However, skin is not the most advantageous transplant site due to the robust mechanical property and deficient physiological perfusion. Herein, a subcutaneous space made of prevascularized collagen fibers (PVCF) generated by controlling the duration of in situ foreign body reaction is reported. In contrast to skin, an optimally preprogrammed PVCF presents a larger tissue volume (171 mm3), low Young's modulus (1/2‐fold), high flexibility high mechanical energy dissipation rate (1.3‐fold), highly permeable surface structure, and plentiful vascular network. Remarkably, cells transplanted into PVCF suffer less apoptosis and necrosis, and generate more mature hairs (≈289 per site) than that in intracutaneous transplantation (≈177 per site). The RNA‐sequencing profiling indicates similar trends under molecular level. This work provides a promising strategy to improve graft site microenvironment physiologically and mechanically, with a low‐cost and simple fabrication process.

中文翻译:

在可控异物反应形成的血管形成前的组织空间中再生头发

Trichogenic细胞的皮内移植是目前认可的在体内实现头发再生的策略。但是,由于强大的机械性能和不足的生理灌注,皮肤并不是最有利的移植部位。这里,报道了通过控制原位异物反应的持续时间而产生的由血管前胶原纤维(PVCF)制成的皮下空间。与皮肤相比,最佳预编程的PVCF具有更大的组织体积(171 mm 3),低杨氏模量(1/2倍),高柔韧性,高机械能耗散率(1.3倍),高渗透性的表面结构和丰富的血管网络。值得注意的是,移植到PVCF中的细胞比皮内移植(每个位置≈177个)的细胞凋亡和坏死少,并能产生更多的成熟毛发(每个位置289个)。RNA序列分析表明在分子水平上也有相似的趋势。这项工作提供了一种有前途的策略,可以以低成本和简单的制造工艺从生理和机械角度改善移植部位的微环境。
更新日期:2020-11-23
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