Acidic pH levels are often observed in growing tumors, with profound effects on cancer cells and surrounding microenvironment. In this issue of Developmental Cell, Funato et al. (2020) show that expression of oncogenic phosphatase of regenerating liver 3 (PRL3) shifts cellular preference for environmental pH, leading to acid addiction.

中文翻译：

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沉迷于酸性微环境

在生长中的肿瘤中经常观察到酸性pH值，对癌细胞和周围的微环境产生深远的影响。在本期《发育细胞》中，Funato等人。（2020年）表明再生肝3（PRL3）的致癌磷酸酶的表达改变了细胞对环境pH的偏爱，导致了酸成瘾。