Biochimica et Biophysica Acta (BBA) - General Subjects ( IF 3 ) Pub Date : 2020-11-22 , DOI: 10.1016/j.bbagen.2020.129801 Cagla Celik , Ayse Gencay , Ismail Ocsoy
Background
Due to lack of approved drugs and vaccines, the medical world has resorted to older drugs, produced for viral infections and other diseases, as a remedy to combat COVID-19. The accumulating evidence from in vitro and in vivo studies for SARS-CoV and MERS-CoV have demonstrated that several polyphenols found in plants and zinc- polyphenol clusters have been in use as herbal medicines have antiviral activities against viruses with various mechanisms.
Scope of review
Curcumin, zinc and zinc-ionophores have been considered as nutraceuticals and nutrients showing great antiviral activities with their medicinal like activities.
Major conclusions
In this work, we discussed the potential prophylactic and/or therapeutic effects of curcumin, zinc and zinc-ionophores in treatment of viral infections including COVID-19.
General significance
Curcuminoids and Zinc classified as nutraceuticals under GRAS (Generally Recognized As Safe) by FDA can provide complementary treatment for COVID 19 patients with their immunity-boosting and antiviral properties.
中文翻译:
可以在对抗COVID 19大流行中部署食品和食品补充剂吗?
背景
由于缺乏经过批准的药物和疫苗,医学界已经采用了为病毒感染和其他疾病而生产的较旧药物,作为对抗COVID-19的一种补救措施。来自SARS-CoV和MERS-CoV的体外和体内研究的越来越多的证据表明,植物中发现的几种多酚和锌-多酚簇已被用作草药,具有多种机制的抗病毒活性。
审查范围
姜黄素,锌和锌离子载体已被视为营养品和营养物质,并具有类似药物的活性,具有很好的抗病毒活性。
主要结论
在这项工作中,我们讨论了姜黄素,锌和锌离子载体在治疗包括COVID-19在内的病毒感染中的潜在预防和/或治疗作用。
一般意义
FDA根据GRAS(通常公认安全)将姜黄素和锌归类为营养保健品,可通过其增强免疫力和抗病毒特性为COVID 19患者提供补充治疗。