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Numerical investigation of patient-specific thoracic aortic aneurysms and comparison with normal subject via computational fluid dynamics (CFD)
Medical & Biological Engineering & Computing ( IF 3.2 ) Pub Date : 2020-11-22 , DOI: 10.1007/s11517-020-02287-6
Mustafa Etli 1 , Gokhan Canbolat 2 , Oguz Karahan 1 , Murat Koru 3
Affiliation  

Vascular hemodynamics play an important role in cardiovascular diseases. This work aimed to investigate the effects of an increase in ascending aortic diameter (AAD) on hemodynamics throughout a cardiac cycle for real patients. In this study, two scans of thoracic aortic aneurysm (TAA) subject with different AADs (42.94 mm and 48.01 mm) and a scan of a normal subject (19.81 mm) were analyzed to assess the effects of hemodynamics on the progression of TAA with the same flow rate. Real-patient aortic geometries were scanned by computed tomography angiography (CTA), and steady and pulsatile flow conditions were used to simulate real patient aortic geometries. Aortic arches were obtained from routine clinical scans. Computational fluid dynamics (CFD) simulations were performed with in vivo boundary conditions, and 3D Navier-Stokes equations were solved by a UDF (user-defined function) code defining a real cardiac cycle of one patient using Fourier series (FS). Wall shear stress (WSS) and pressure distributions were presented from normal subject to TAA cases. The results show that during the peak systolic phase pressure load increased by 18.56% from normal subject to TAA case 1 and by 23.8% from normal subject to TAA case 2 in the aneurysm region. It is concluded that although overall WSS increased in aneurysm cases but was low in dilatation areas. As a result, abnormal changes in WSS and higher pressure load may lead to rupture and risk of further dilatation. CFD simulations were highly effective to guide clinical predictions and assess the progress of aneurysm regions in case of early surgical intervention.



中文翻译:

通过计算流体动力学 (CFD) 对患者特异性胸主动脉瘤进行数值研究并与正常受试者进行比较

血管血流动力学在心血管疾病中起重要作用。这项工作旨在研究升主动脉直径 (AAD) 的增加对真实患者整个心动周期中血流动力学的影响。在这项研究中,分析了具有不同 AAD(42.94 毫米和 48.01 毫米)的胸主动脉瘤(TAA)受试者的两次扫描和正常受试者(19.81 毫米)的扫描,以评估血流动力学对 TAA 进展的影响相同的流速。通过计算机断层扫描血管造影 (CTA) 扫描真实患者的主动脉几何形状,并使用稳定和脉动流条件来模拟真实患者的主动脉几何形状。从常规临床扫描获得主动脉弓。计算流体动力学 (CFD) 模拟是在体内边界条件下进行的,和 3D Navier-Stokes 方程通过 UDF(用户定义函数)代码求解,该代码使用傅立叶级数 (FS) 定义了一名患者的真实心动周期。壁面剪切应力 (WSS) 和压力分布从正常受试者到 TAA 情况呈现。结果表明,在动脉瘤区域的收缩期峰值压力负荷从正常受试者到 TAA 病例 1 增加了 18.56%,从正常受试者到 TAA 病例 2 增加了 23.8%。得出的结论是,虽然总体WSS在动脉瘤病例中增加,但在扩张区域较低。因此,WSS 的异常变化和更高的压力负荷可能导致破裂和进一步扩张的风险。在早期手术干预的情况下,CFD 模拟非常有效地指导临床预测和评估动脉瘤区域的进展。

更新日期:2020-11-23
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