The aim of this study was to investigate the effect of using subantimicrobial dose doxycycline as an adjunct in periodontitis stage 2, grade B in subjects with type 2 diabetes mellitus. A total of thirty patients were divided into the following two groups with reference to periodontitis, type 2 diabetes mellitus, and administration of the doxycycline drug: Group I: patients with periodontitis stage 2, grade B and type 2 diabetes mellitus who received SRP only. Group II: patients with periodontitis stage 2, grade B and type 2 diabetes mellitus who received SRP and doxycycline 20 mg. The following clinical measurements were recorded at baseline (prior to scaling and root planning) and after one and three months postoperatively: GI, PI, and PD with a periodontal calibrated probe. The levels of both MMP-9 and MMP-13, from 60 GCF samples, were analyzed by ELISA. Patients treated with SRP and doxycycline 20 mg showed a significant reduction of PD, PI, GI, MMP-9, and MMP-13 than patients who received SRP only. Improvements in parameters clinically and biochemically were observed following the adjunctive use of doxycycline subantimicrobial dose therapy for the management of stage 2, grade B periodontitis patients with type 2 diabetes mellitus.

中文翻译：

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亚抗菌剂量多西环素治疗对 2 型糖尿病患者牙周炎 2 期 B 级龈沟液中 MMP-9 和 MMP-13 水平的影响

本研究的目的是调查使用亚抗菌剂量多西环素作为辅助治疗 2 型糖尿病患者 B 级牙周炎 2 期的效果。参考牙周炎、2 型糖尿病和多西环素药物的给药，总共 30 名患者被分为以下两组： I 组：牙周炎 2 期、B 级和 2 型糖尿病患者，仅接受 SRP。第二组：接受 SRP 和强力霉素 20 mg 的牙周炎 2 期、B 级和 2 型糖尿病患者。在基线（刮治和牙根规划之前）和术后 1 个月和 3 个月后记录以下临床测量值：GI、PI 和 PD，使用牙周校准探针。MMP-9 和 MMP-13 的水平，来自 60 个 GCF 样品，通过ELISA进行分析。与仅接受 SRP 的患者相比，接受 SRP 和多西环素 20 mg 治疗的患者的 PD、PI、GI、MMP-9 和 MMP-13 显着降低。在辅助使用多西环素亚抗菌剂量疗法治疗 2 期 B 级牙周炎伴 2 型糖尿病患者后，观察到临床和生化参数的改善。