After cardiac valve replacement, most patients will have different degrees of thrombosis, different parts of the thrombus, and even more frequent occurrence of postoperative thrombosis; therefore, the prevention of postoperative thrombosis is particularly important. The purpose of this study was to investigate the preventive effect of albumin nano tPA gene plasmid ultrasound microbubble carrier system on thrombosis, especially in cardiac valve. The experimental control method was used. Firstly, 11 dogs meeting the experimental requirements were selected. Secondly, the data of albumin nanoparticles and microbubbles were analyzed. The average size of albumin particles was 132.0 nm, the average size of microbubbles was 3.1 ± 1.6 μm, and the zeta potential was 13.70 ± 1.95 MV. The concentration of microbubbles was 4.2 ± 1.3 × 10/ml. Finally, 11 dogs were divided into two groups. The experimental group was treated with albumin nanoparticles ultrasound microbubble, and the others were the control group. It was found that the levels of tPA and D-dimer in the experimental group were significantly increased and maintained at a high level at 1 week after operation, and the prothrombin time was detected and the international normalized ratio was calculated at the same time. No significant changes were found in the experimental group.

中文翻译：

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白蛋白纳米TPA基因质粒超声微泡载体系统对心脏瓣膜置换术后血栓形成的预防作用

心脏瓣膜置换术后，大部分患者会出现不同程度的血栓、不同部位的血栓，甚至术后血栓发生的频率更高；因此，术后血栓形成的预防尤为重要。本研究旨在探讨白蛋白纳米tPA基因质粒超声微泡载体系统对血栓形成，尤其是心脏瓣膜形成的预防作用。采用实验控制方法。首先，选择符合实验要求的11只犬。其次，分析了白蛋白纳米颗粒和微泡的数据。白蛋白颗粒平均粒径为 132.0 nm，微泡平均粒径为 3.1 ± 1.6 μm，zeta 电位为 13.70 ± 1.95 MV。微泡浓度为 4.2 ± 1.3 × 10/ml。最后，11只狗被分成两组。实验组给予白蛋白纳米颗粒超声微泡治疗，其余为对照组。发现实验组tPA和D-二聚体水平在术后1周显着升高并维持在高水平，同时检测凝血酶原时间并计算国际标准化比值。实验组未发现明显变化。同时检测凝血酶原时间并计算国际标准化比值。实验组未发现明显变化。同时检测凝血酶原时间并计算国际标准化比值。实验组未发现明显变化。