ABSTRACT

It is commonly assumed that cerebral asymmetry is unidimensional, but evidence increasingly suggests that different brain circuits are independently lateralized. This might explain why the search for a laterality gene has provided multiple candidates, each with weak linkage. An alternative possibility is that there is a single genetically invariant source of lateralization, perhaps cytoplasmic, and subject to many influences, some genetic, some epigenetic, and some random. This could further explain why laterality is associated with a variety of disorders, such as dyslexia, schizophrenia, stress disorders, and depression.

中文翻译：

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多少偏方？

摘要

人们普遍认为大脑不对称是一维的，但越来越多的证据表明不同的大脑回路是独立的。这或许可以解释为什么对偏侧性基因的搜索提供了多个候选者，每个候选者都具有弱连锁。另一种可能性是存在单一的遗传不变的侧化源，可能是细胞质的，并受到许多影响，一些是遗传的，一些是表观遗传的，一些是随机的。这可以进一步解释为什么偏侧性与多种疾病有关，例如阅读障碍、精神分裂症、压力障碍和抑郁症。