Studies in the past 15 years have highlighted the role of the gut microbiota in modulation of host metabolism. The observation that germ‐free (GF) mice are leaner than conventionally raised (CONV) mice and their apparent resistance to diet‐induced obesity (DIO), sparked the interest in dissecting the possible causative role of the gut microbiota in obesity and metabolic diseases. However, discordant results among studies leave such relationship elusive.

中文翻译：

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无菌小鼠不受饮食诱导的肥胖和代谢功能障碍的保护

过去 15 年的研究强调了肠道微生物群在调节宿主代谢中的作用。观察到无菌 (GF) 小鼠比常规饲养的 (CONV) 小鼠更瘦，并且它们对饮食诱导的肥胖 (DIO) 具有明显的抵抗力，这激发了人们对剖析肠道微生物群在肥胖和代谢疾病中可能的致病作用的兴趣. 然而，研究之间不一致的结果使这种关系难以捉摸。