Human prion diseases (PrDs) are a group of fatal and transmissible neurodegenerative disorders that are diagnosed definitively in post mortem brains. Calmodulin (CaM) is a ubiquitous calcium‐binding protein. Increased brain CaM level has been reported in prion‐infected rodent models and some scrapie‐infected cells. However, the putative alteration of CaM in cerebrospinal fluid (CSF) of human PrDs is uncertain. Here, we try to figure out the profiles of CSF CaM in sporadic Creutzfeldt‐Jacob disease.

中文翻译：

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散发性克雅氏病患者脑脊液中钙调素水平显着升高

人类朊病毒病 (PrDs) 是一组致命的、可传染的神经退行性疾病，在死后大脑中得到明确诊断。钙调蛋白 (CaM) 是一种普遍存在的钙结合蛋白。据报道，在感染朊病毒的啮齿动物模型和一些感染瘙痒病的细胞中，脑 CaM 水平升高。然而，人类 PrDs 脑脊液 (CSF) 中 CaM 的推定改变尚不确定。在这里，我们试图弄清楚 CSF CaM 在散发性 Creutzfeldt-Jacob 病中的特征。