The analysis of the immune gene expression was performed in Zebu × Holstein calves with resistant and susceptible phenotypes naturally infected with Cooperia punctata. Fourteen calves of 4 months old were grazed for 11 weeks under a tropical climate. The parasitic infection showed an average epg value of 1055 ± 1155 and an IgG optical density of 0.814 ± 0.0.037 with statistic differences among the different weeks (p < 0.05), and a pcv value of 24 ± 2.0 % (p > 0.05). High variation in epg value was observed, between 7 ± 7.14 and 4657 ± 1886, and, based on these differences; the infected hosts were classified as five resistant calves with epg ≤ 200 and nine susceptible calves with epg ≥ 300. Moreover, IgG levels displayed statistical differences between resistance and susceptible calves to C. punctata infection. The immune gene expression was analysed in three resistant and susceptible calves, respectively. Nine cytokine genes and the FCεR1A receptor were analysed at the 3rd and 11th weeks post-infection. In the first period upregulation was found, from 2.19- to 9.45-fold, (p < 0.05) for IL-2, -5, - 6, -10, TGF-β and FCεR1A in the resistant group; the expression was decreased at the 11th week with low level of IgG. In contrast, downregulation for susceptible calves was found for nine immune genes and upregulation for INF-γ in both periods together with increased IgG levels. In conclusion, immune gene expression was regulated at the begging infection of C. punctata in resistant grazing calves. In contrast, suppression of important genes was involved in calves susceptible to C. punctata.

分析免疫基因表达的Zebu×荷斯坦犊牛具有抗性和易感表型的自然感染了点苍白。在热带气候下，将14个4个月大的小牛放牧11周。寄生虫感染的平均epg值为1055±1155，IgG光密度为0.814±0.0.037，不同周之间的统计差异（p <0.05），pcv值为24±2.0％（p> 0.05） 。在这些差异的基础上，观察到的epg值变化很大，介于7±7.14和4657±1886之间。被感染的宿主分为epg≤200的五只抗性小牛和epg≥300的九只易感小牛。此外，IgG水平显示抗性和易感小牛之间的统计学差异。C.点状感染。分别在三种抗性和易感性犊牛中分析了免疫基因的表达。在感染后第3周和第11周分析了9种细胞因子基因和FCεR1A受体。在第一阶段，耐药组中IL-2，-5，-6，-10，TGF-β和FCεR1A的上调为2.19-9.45倍，（p <0.05）。IgG水平低时，在第11周表达降低。相比之下，两个时期发现易感犊牛的下调和两个时期INF-γ的上调以及IgG水平的增加。总之，免疫基因表达在点状梭状芽胞杆菌感染中得到调节。在抗性放牧犊牛中。相反，重要基因的抑制与易患点状梭菌的小牛有关。