Rational design of biocompatible nanoplatforms simultaneously realizing multimodal imaging and therapeutic functions is meaningful to cancer treatment. Herein, the MoS₂–CuO heteronanocomposites are designed by integrating semiconductor CuO and flower-like MoS₂ via a two-step hydrothermal method. After loading bovine serum albumin (BSA) and immunoadjuvant imiquimod (R837), the obtained MoS₂–[email protected]/R837 (MCBR) nanoplatforms realize the excellent computed tomography/infrared thermal/magnetic resonance multi-mode bioimaging as well as significantly enhanced antitumor efficacy of synergetic photothermal therapy (PTT)/chemodynamic therapy (CDT)/immunotherapy. In this nanoplatform, the semiconductor CuO exhibits peroxidase-like activity, which can react with over-expressed H₂O₂ in tumor microenvironment (TME) to generate OH for CDT via Haber-Weiss and Fenton-like reactions. And this process can be further accelerated by the generated heat of MoS₂ under 808 nm laser irradiation. More importantly, the obtained multifunctional MCBR nanoplatforms under near-infrared (NIR) irradiation would destroy tumor cells to generate tumor associated antigens (TAAs), which combine with R837 as an adjuvant to trigger strong antitumor immune responses for effectively eliminating primary tumors and metastatic tumors.

同时实现多模式成像和治疗功能的生物相容性纳米平台的合理设计对癌症治疗意义重大。本文中，通过两步水热法将半导体CuO和花状MoS ₂集成在一起，设计了MoS ₂ -CuO杂纳米复合材料。加载牛血清白蛋白（BSA）和免疫佐剂咪喹莫特（R837）后，获得的MoS ₂– [受电子邮件保护] / R837（MCBR）纳米平台可实现出色的计算机断层扫描/红外热/磁共振多模式生物成像，以及协同光热疗法（PTT）/化学动力学疗法（CDT）/免疫疗法的显着增强的抗肿瘤功效。在该纳米平台中，半导体CuO表现出过氧化物酶样活性，可与肿瘤微环境（TME）中过表达的H ₂ O ₂反应，通过Haber-Weiss和Fenton样反应生成CDT的OH。MoS ₂产生的热量可以进一步加速该过程在808 nm激光照射下 更重要的是，在近红外（NIR）辐射下获得的多功能MCBR纳米平台将破坏肿瘤细胞以产生肿瘤相关抗原（TAA），并与R837结合使用以触发强大的抗肿瘤免疫反应，从而有效消除原发性肿瘤和转移性肿瘤。