Objective

Alcohol use disorder (AUD) is highly comorbid with other substance use disorders (SUDs) as well as other psychiatric disorders, such as anxiety, depression, and Borderline Personality Disorder (BPD). However, studies of persons with AUD rarely account for its comorbidity with other SUDs. Some research suggests that BPD symptoms reflect an important connection between internalizing disorders and SUDs.

The current study investigated

1. The levels of trait anxiety and symptoms of depression and BPD in persons with an AUD as a function of comorbid SUDs (cannabis use disorder – CUD) and other substance use disorder (oSUD), and 2. The influence of BPD on the association between severity of overall lifetime SUD symptoms (AUD + CUD + oSUD) and both trait anxiety and symptoms of depression.

Method

Trait anxiety and symptoms of depression and BPD were assessed in 671 young adults (351 men; 320 women; mean age 21 years) separated into four groups: Controls (n=185), AUD-only (134), AUD+CUD (n=210), and AUD + oSUD (n=142).

Results

Trait anxiety and symptoms of depression and BPD were elevated in all AUD groups compared with controls, and in the AUD+oSUD group compared with all other groups as well. Structural models also indicated that BPD symptoms accounted for all of the variance in lifetime SUD symptoms associated with Trait Anxiety, and a significant portion of the variance in lifetime SUD symptoms associated with depression symptoms.

Conclusion

Results indicate that when AUD is comorbid with oSUD, it is associated with more severe AUD symptoms and higher levels of trait anxiety and symptoms of both depression and BPD. The results also indicate that BPD symptoms account for the majority of the variance in SUD symptoms associated with both trait anxiety and depression, suggesting that a considerable amount of the internalizing symptomatology in AUD/SUDs is associated with BPD psychopathology.

中文翻译：

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伴有和不伴有物质使用障碍的酒精使用障碍中的焦虑、抑郁和边缘人格的症状

客观的

酒精使用障碍 (AUD) 与其他物质使用障碍 (SUD) 以及其他精神障碍（例如焦虑、抑郁和边缘型人格障碍 (BPD)）高度共存。然而，对 AUD 患者的研究很少解释其与其他 SUD 的合并症。一些研究表明，BPD 症状反映了内化障碍和 SUD 之间的重要联系。

目前的研究调查了

1. AUD 患者的特质焦虑、抑郁症状和 BPD 水平与 SUD（大麻使用障碍 – CUD）和其他物质使用障碍 (oSUD) 共病的函数关系，以及 2. BPD 对关联的影响终生 SUD 症状（AUD + CUD + oSUD）的严重程度与特质焦虑和抑郁症状的严重程度之间的关系。

方法

在 671 名年轻人（351 名男性；320 名女性；平均年龄 21 岁）中评估了特质焦虑和抑郁症和 BPD 症状，分为四组：对照组（n=185）、仅 AUD（134）、AUD+CUD（n =210)，澳元 + oSUD (n=142)。

结果

与对照组相比，所有 AUD 组的特质焦虑、抑郁和 BPD 症状均升高，与所有其他组相比，AUD+oSUD 组也有所升高。结构模型还表明，BPD 症状解释了与特质焦虑相关的终生 SUD 症状的所有变化，以及与抑郁症状相关的终生 SUD 症状变化的很大一部分。

结论

结果表明，当 AUD 与 oSUD 共病时，它与更严重的 AUD 症状和更高水平的特质焦虑以及抑郁和 BPD 的症状相关。结果还表明，BPD 症状是与特质焦虑和抑郁相关的 SUD 症状变化的大部分原因，这表明 AUD/SUD 中相当多的内化症状与 BPD 精神病理学有关。