The consumption of high-fat and high-sugar diets, in the form of junk food, and binge eating are now common. Increasing evidence suggests that a high-fat diet (HFD) can induce neuroinflammation and alter behavior. I aimed to study the effects of diets of differing fat content on neuroinflammation and spatial memory using an object–place (OP) task. Thirty-two adult male rats were allocated to four groups and fed a regular diet (Regular diet), a control diet (Control diet), an HFD (60% of calories from lard), or a high-coconut oil diet (HCOD; 60% of calories from coconut oil) for 3 days. Their water intake, food consumption, body mass, and metabolic variables were measured. HFD-fed rats showed significantly poorer performance on the OP task, as assessed using the discrimination index (− 0.208 ± 0.094), than the Regular (0.462 ± 0.078; P < 0.0001) and Control (0.379 ± 0.081; P = 0.0003) groups. However, no significant difference was observed in spatial memory between the HCOD and Regular groups. The concentrations of neuroinflammatory markers (interleukin [IL]-1β, IL-6, tumor necrosis factor α, and nuclear factor κB) were also measured in the hippocampus and prefrontal cortex. HFD-fed rats showed significantly higher levels of neuroinflammatory markers than the Regular and Control diet-fed groups. HCOD feeding did not induce neuroinflammation in the hippocampus and prefrontal cortex compared with the Regular and Control groups.

以垃圾食品的形式食用高脂肪和高糖饮食以及暴饮暴食现在很常见。越来越多的证据表明，高脂肪饮食 (HFD) 会诱发神经炎症并改变行为。我的目的是使用对象位置 (OP) 任务来研究不同脂肪含量的饮食对神经炎症和空间记忆的影响。将 32 只成年雄性大鼠分为四组，分别喂食常规饮食（Regular diet）、对照饮食（Control diet）、HFD（60% 的卡路里来自猪油）或高椰子油饮食（HCOD； 60% 的卡路里来自椰子油），持续 3 天。测量了他们的水摄入量、食物消耗量、体重和代谢变量。HFD 喂养的大鼠在 OP 任务中表现出明显较差的表现，使用辨别指数 (- 0.208 ± 0.094) 进行评估，比常规 (0.462 ± 0.078;P  < 0.0001) 和对照组 (0.379 ± 0.081; P  = 0.0003) 组。然而，在 HCOD 组和常规组之间的空间记忆中没有观察到显着差异。还在海马和前额叶皮层中测量了神经炎症标志物（白细胞介素 [IL]-1β、IL-6、肿瘤坏死因子 α 和核因子 κB）的浓度。HFD 喂养的大鼠的神经炎症标志物水平显着高于常规和对照饮食喂养组。与常规组和对照组相比，HCOD 喂养不会诱导海马和前额叶皮层的神经炎症。