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Needle-compatible miniaturized optoelectronic sensor for pancreatic cancer detection
Science Advances ( IF 13.6 ) Pub Date : 2020-11-20 , DOI: 10.1126/sciadv.abc1746
Seung Yup Lee 1 , Julia M Pakela 2, 3 , Kyounghwan Na 4 , Jiaqi Shi 5 , Barbara J McKenna 5 , Diane M Simeone 6 , Euisik Yoon 1, 4 , James M Scheiman 7 , Mary-Ann Mycek 1, 2, 8
Affiliation  

Pancreatic cancer is one of the deadliest cancers, with a 5-year survival rate of <10%. The current approach to confirming a tissue diagnosis, endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), requires a time-consuming, qualitative cytology analysis and may be limited because of sampling error. We designed and engineered a miniaturized optoelectronic sensor to assist in situ, real-time, and objective evaluation of human pancreatic tissues during EUS-FNA. A proof-of-concept prototype sensor, compatible with a 19-gauge hollow-needle commercially available for EUS-FNA, was constructed using microsized optoelectronic chips and microfabrication techniques to perform multisite tissue optical sensing. In our bench-top verification and pilot validation during surgery on freshly excised human pancreatic tissues (four patients), the fabricated sensors showed a comparable performance to our previous fiber-based system. The flexibility in source-detector configuration using microsized chips potentially allows for various light-based sensing techniques inside a confined channel such as a hollow needle or endoscopy.



中文翻译:

用于胰腺癌检测的针兼容微型光电传感器

胰腺癌是最致命的癌症之一,5 年生存率<10%。目前确认组织诊断的方法,即内窥镜超声引导下细针穿刺 (EUS-FNA),需要耗时的定性细胞学分析,并且可能由于采样错误而受到限制。我们设计并设计了一种小型光电传感器,以协助在 EUS-FNA 期间对人类胰腺组织进行原位、实时和客观的评估。使用微型光电芯片和微细加工技术构建了一个概念验证原型传感器,该传感器与可用于 EUS-FNA 的 19 号空心针兼容,以执行多部位组织光学传感。在我们对新鲜切除的人类胰腺组织(四名患者)进行手术期间的台式验证和试点验证中,制造的传感器显示出与我们之前基于光纤的系统相当的性能。使用微型芯片的源探测器配置的灵活性可能允许在受限通道内使用各种基于光的传感技术,例如空心针或内窥镜。

更新日期:2020-11-21
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