Science ( IF 41.845 ) Pub Date : 2020-11-20 , DOI: 10.1126/science.370.6519.997 Kendall Powell
A healthy gut microbiome seems to be required for immuno-oncology therapies designed to turn up the body's immune response to attack tumors. Researchers have many “black boxes” to fill in on how gut microbes directly or indirectly influence the T cells unleashed by immune checkpoint inhibitor therapies. But several groups are betting that microbiome-based therapies can help more patients respond to immunotherapies and become one of the biggest breakthroughs in cancer treatment in decades.
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