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Full-spectrum responsive WO3−x@HA nanotheranostics for NIR-II photoacoustic imaging-guided PTT/PDT/CDT synergistic therapy
Inorganic Chemistry Frontiers ( IF 7 ) Pub Date : 2020-11-11 , DOI: 10.1039/d0qi01249a
Yanwen Ding 1, 2, 3, 4, 5 , Rongtao Huang 1, 2, 3, 4, 5 , Liuruiqi Luo 1, 2, 3, 4, 5 , Wenwei Guo 1, 2, 3, 4, 5 , Chengyuan Zhu 1, 2, 3, 4, 5 , Xing-Can Shen 1, 2, 3, 4, 5
Affiliation  

The selection of second near-infrared (NIR-II) window-responsive nanotheranostics is significant for precise cancer treatments. In this work, a full-spectrum responsive multifunctional WO3-based nanotheranostic was produced to accomplish NIR-II photoacoustic (PA) imaging-guided photothermal therapy (PTT), photodynamic therapy (PDT) and chemodynamic therapy (CDT) synergistic therapy. For this purpose, oxygen vacancies were formed in WO3, which narrows the band gap and allows WO3−x to absorb over the full spectrum. The WO3−x@HA nanotheranostic was constructed with the successive surface modification of hyaluronic acid (HA) to improve the water dispersibility and tumour targeting efficiency. Upon activation with NIR-II irradiation, WO3−x@HA showed excellent photothermal conversion, reactive oxygen species (ROS) production and a high-resolution photoacoustic (PA) imaging ability. Meanwhile, WO3−x@HA exhibited both Fenton-like reaction and glutathione (GSH) depletion properties; the effective photothermal conversion ability of WO3−x@HA elevates the local temperature and accelerates the Fenton-like process to achieve enhanced PTT/PDT/CDT. The formation of oxygen vacancies was proved to be key to the photothermal, photodynamic and chemodynamic properties of WO3−x@HA, and the corresponding possible mechanisms were proposed. In vitro and in vivo experiments have confirmed that WO3−x@HA has a PTT/PDT/CDT synergistic therapy effect for tumour ablation under real-time NIR-II PA imaging guidance. Therefore, WO3−x@HA reveals the potential for NIR-II irradiation-activated precise theranostics for PA imaging-guided tumour-targeting PTT/PDT/CDT synergistic therapy.

中文翻译:

用于NIR-II光声成像引导的PTT / PDT / CDT协同治疗的全光谱响应式WO3-x @ HA纳米治疗

选择第二种近红外(NIR-II)窗口响应纳米热疗技术对于精确的癌症治疗具有重要意义。在这项工作中,生产了一种基于全光谱的多功能WO 3基纳米热疗药,以完成NIR-II光声(PA)成像引导的光热疗法(PTT),光动力疗法(PDT)和化学动力疗法(CDT)协同疗法。为此,在WO 3中形成了氧空位,这使带隙变窄并且允许WO 3- x在整个光谱上吸收。WO 3- x通过透明质酸(HA)的连续表面修饰来构建@HA纳米热能,以提高水分散性和肿瘤靶向效率。通过NIR-II辐射活化后,WO 3- x @HA显示出出色的光热转化,活性氧(ROS)产生和高分辨率的光声(PA)成像能力。同时,WO 3- x @HA同时表现出Fenton样反应和谷胱甘肽(GSH)耗尽特性。WO 3- x的有效光热转化能力@HA升高局部温度并加速类似于Fenton的过程,以实现增强的PTT / PDT / CDT。氧空位的形成被证明是WO 3- x @HA的光热,光动力和化学动力性质的关键,并提出了相应的可能机理。体外体内实验已经证实,WO 3- x @HA在实时NIR-II PA成像指导下具有PTT / PDT / CDT协同治疗肿瘤消融的作用。因此,WO 3- x @HA揭示了NIR-II辐照激活的精确治疗方法在PA成像引导的肿瘤靶向PTT / PDT / CDT协同治疗中的潜力。
更新日期:2020-12-17
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