A catalytic reaction using syngas (CO/H₂) as feedstock for the selective β-methylation of alcohols was developed whereby carbon monoxide acts as a C1 source and hydrogen gas as a reducing agent. The overall transformation occurs through an intricate network of metal-catalyzed and base-mediated reactions. The molecular complex [Mn(CO)₂Br[HN(C₂H₄PⁱPr₂)₂]] 1 comprising earth-abundant manganese acts as the metal component in the catalytic system enabling the generation of formaldehyde from syngas in a synthetically useful reaction. This new syngas conversion opens pathways to install methyl branches at sp³ carbon centers utilizing renewable feedstocks and energy for the synthesis of biologically active compounds, fine chemicals, and advanced biofuels.

中文翻译：

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一氧化碳和氢气（合成气）作为选择性催化甲基化的 C1 构件

_{开发了使用合成气 (CO/H 2} ) 作为原料对醇进行选择性 β-甲基化的催化反应，其中一氧化碳作为 C1 源，氢气作为还原剂。整体转化通过金属催化和碱介导​​反应的复杂网络发生。含有丰富的锰的分子络合物 [Mn(CO) ₂ Br[HN(C ₂ H ₄ P ⁱ Pr ₂ ) ₂ ]] 1作为催化系统中的金属组分，能够在合成气中从合成气中生成甲醛。有用的反应。^{这种新的合成气转化开辟了在 sp 3}处安装甲基分支的途径碳中心利用可再生原料和能源合成生物活性化合物、精细化学品和先进的生物燃料。