A major thrust in the concept of green chemistry is to eliminate the production of hazardous materials. Thus, sustainable toxicity testing is required for its successful implementation. Here, we present the principles of green toxicology, a concept less well known than green chemistry, but indispensable for the sustainable development of chemical products. Green toxicology entails early testing through non-animal methods, such as novel in vitro and in silico technologies in toxicity prediction, to obtain benign products in benign processes with reduced exposure. The future of non-testing toxicity prediction entails both an improved creation, management, and use of big data to optimize chemical space coverage and an increased mechanistic and biological pathway understanding which can be integrated in prediction tools. This perspective provides an introduction to chemists and toxicologists to the combined idea of green toxicology, rather than providing a comprehensive overview. Specifically, we (1) provide a brief overview of recently emerging technologies, (2) highlight the importance of collaboration between researchers to implement and integrate green toxicology in the chemical industry, and (3) present challenges that come along with the emerging technologies and propose possibilities for their better application and wider use in the future.

中文翻译：

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绿色毒理学：连接绿色化学与现代毒理学

绿色化学概念的一个主要推动力是消除有害物质的生产。因此，其成功实施需要可持续的毒性测试。在这里，我们介绍绿色毒理学的原理，这个概念不如绿色化学广为人知，但对化学产品的可持续发展必不可少。绿色毒理学需要通过非动物方法进行早期测试，例如新的体外和计算机毒性预测技术，在减少暴露的良性过程中获得良性产品。非测试毒性预测的未来既需要改进大数据的创建、管理和使用，以优化化学空间覆盖范围，也需要增加可集成到预测工具中的机械和生物途径理解。这种观点向化学家和毒理学家介绍了绿色毒理学的综合理念，而不是提供全面的概述。具体而言，我们 (1) 简要概述了最近出现的技术，(2) 强调了研究人员之间合作以在化学工业中实施和整合绿色毒理学的重要性，