Abstract The purpose of the present investigation was to prepare pH-sensitive hydrogels from photo-crosslinked poly(ethylene glycol) diacrylate (PEG-DA). Rutile titanium dioxide (TiO2) was employed to modify the PEG-DA hydrogels. The rutile titanium dioxide (TiO2) nanoparticles were prepared by direct oxidation of titanium in the presence of polyethylene glycol (PEG) at high temperature. The nanoparticles were characterized by FT-IR, XRD and SEM. The influence of experimental conditions, such as pH, type and amount of photoinitiators on the release profiles of donepezil hydrochloride (active pharmaceutical ingredient for Alzheimer disease) from modified PEG-DA hydrogels, was investigated. The drug release processes were analyzed kinetically using zero-order, first-order, Hixson-Crowell and Peppas models.

中文翻译：

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光交联聚（乙二醇）二丙烯酸酯掺入二氧化钛的 pH 敏感水凝胶的制备和表征

摘要 本研究的目的是从光交联聚乙二醇二丙烯酸酯 (PEG-DA) 制备 pH 敏感水凝胶。金红石二氧化钛 (TiO2) 被用来修饰 PEG-DA 水凝胶。金红石型二氧化钛 (TiO2) 纳米粒子是通过在聚乙二醇 (PEG) 存在下在高温下直接氧化钛来制备的。通过FT-IR、XRD和SEM对纳米颗粒进行表征。研究了实验条件（例如 pH 值、光引发剂的类型和数量）对盐酸多奈哌齐（治疗阿尔茨海默病的活性药物成分）从改性 PEG-DA 水凝胶的释放曲线的影响。使用零级、一级、Hixson-Crowell 和 Peppas 模型对药物释放过程进行动力学分析。