Autografts and allografts are currently considered the gold standard for grafting surgery; however, to meet the growing demand in fast-aging societies, synthetic biomaterials will play an increasingly important role. Here we report a biodegradable scaffold material composed of recombinant polypeptide based on the human type I collagen alpha 1 chain (RCPhC1) as a source of hydrogel-based graft materials. The flexibility to engineer ideal characteristics for bone grafts was demonstrated. The critical internal isotropic pore structure was generated through a designed thin-layer freeze casting process. The optimized biodegradation rate was controlled by dehydrothermal crosslinking by adjusting the amino acid composition of RCPhC1. As a result, RCPhC1 bone grafts manufactured by a highly scalable streamlined production protocol induced robust regeneration of mature bone tissue while being completely resorbed in pre-clinical animal models.

自体移植和同种异体移植目前被认为是移植手术的金标准。但是，为了满足快速老龄化社会不断增长的需求，合成生物材料将发挥越来越重要的作用。在这里，我们报告了一种可生物降解的支架材料，该材料由基于人类I型胶原蛋白α1链（RCPhC1）的重组多肽组成，是基于水凝胶的移植材料的来源。展示了设计理想的植骨特性的灵活性。关键的内部各向同性孔结构是通过设计的薄层冷冻浇铸工艺产生的。通过调节RCPhC1的氨基酸组成，通过脱氢交联来控制最佳生物降解速率。结果是，