The CRISPR-Cas toolbox allows genetic manipulation of cultured cells, plants and animals on the basis of simpler RNA-guided DNA recognition. It has provided breakthrough scientific opportunities to engineer desirable traits, cure genetic diseases and enable point-of-care diagnostics. A recent study by Joseph Bondy-Denomy and colleagues further equips this toolbox to cut larger chunks of DNA from a cell’s genome.

中文翻译：

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像DNA剪切粘贴工具一样的Pac-Man，可进行更大的基因编辑

CRISPR-Cas工具箱可在更简单的RNA引导的DNA识别的基础上对培养的细胞，植物和动物进行遗传操作。它提供了突破性的科学机会，可以工程化所需的性状，治愈遗传疾病并实现即时诊断。Joseph Bondy-Denomy及其同事的最新研究进一步使该工具箱能够从细胞基因组中切割更大的DNA片段。