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Effects of prolonged subchronic benzo(α)pyrene exposure on rat liver morphology and CYP1A expression during treatment with menadione, quercetin, or tocopherol
Drug and Chemical Toxicology ( IF 2.6 ) Pub Date : 2020-11-19 , DOI: 10.1080/01480545.2020.1849270
M L Perepechaeva 1 , N V Gubanova 2 , A Y Grishanova 1
Affiliation  

Abstract

Arylamines and polycyclic aromatic hydrocarbons (PAHs) are hazardous anthropogenic pollutants in the environment. The toxicity of PAHs, which include benzo(α)pyrene (BP), is mediated by the activation of Р450 cytochromes of the 1А subfamily (CYP1A1 and CYP1A2). Previously, we have demonstrated that tocopherol, quercetin, and menadione inhibit the expression and activity of CYP1A in the liver of male Wistar rats after administration of a high BP dose to the rats for 3 days. Here, we confirmed the effects of tocopherol, quercetin, and menadione on the expression and activity of CYP1A and on rat liver morphology during prolonged administration (90 days) of a low BP dose. We revealed that subchronic oral administration of a low BP dose has no influence on CYP1A expression as compared to controls but can cause pathomorphological changes in rat liver tissue. These changes are abrogated by tocopherol, attenuated by quercetin, and enhanced by menadione.



中文翻译:

甲萘醌、槲皮素或生育酚治疗期间长期亚慢性苯并(α)芘暴露对大鼠肝脏形态和 CYP1A 表达的影响

摘要

芳胺和多环芳烃 (PAHs) 是环境中有害的人为污染物。PAHs(包括苯并(α)芘(BP))的毒性是由 1- 亚家族(CYP1A1 和 CYP1A2)的 Р450 细胞色素的激活介导的。此前,我们已经证明,在给予大鼠高 BP 剂量 3 天后,生育酚、槲皮素和甲萘醌可抑制雄性 Wistar 大鼠肝脏中 CYP1A 的表达和活性。在这里,我们证实了生育酚、槲皮素和甲萘醌对低 BP 剂量长期给药(90 天)期间 CYP1A 的表达和活性以及对大鼠肝脏形态的影响。我们发现,与对照组相比,低 BP 剂量的亚慢性口服给药对 CYP1A 表达没有影响,但会导致大鼠肝组织的病理形态学变化。这些变化被生育酚消除,被槲皮素减弱,被甲萘醌增强。

更新日期:2020-11-19
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