A series of (trifluoromethyl)cyclopropanes (TFCPs) tolerating a broad range of functional groups, known as tert-butyl bioisosteres, have been obtained from the cyclization reaction between nitromethane­ and 5-[β-(trifluoromethyl)styryl]isoxazoles in 70–94% yields and 75:25 to 90:10 dr. This method offers practical access to this cyclopropyl moiety of pharmacological interest, employing an inorganic base under phase-transfer conditions.

中文翻译：

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三氟甲基苯乙烯基恶唑与硝基甲烷的无金属反应合成CF3取代的环丙烷的高效底物诱导方法

从硝基甲烷和5- [β-（三氟甲基）苯乙烯基]异恶唑在70-94之间的环化反应中获得了一系列耐受广泛官能团的（三氟甲基）环丙烷（TFCP），称为叔丁基生物等排体。 ％产率和75:25至90:10 dr。通过在相转移条件下使用无机碱，该方法提供了实用的药理学意义上的环丙基部分的实用途径。