One‐pot synthesis of pyrano[2,3‐c]pyrazole derivatives via two or multicomponent condensation of β‐ketoesters, hydrazine monohydrate/phenyl hydrazine, malononitrile, and substituted benzaldehydes is of great interest not only in synthetic chemistry but also in medicinal chemistry because of the tremendous biological activities, such as anticancer, anti‐inflammatory, analgesic, antimicrobial, and enzyme inhibitory activities exhibited by pyranopyrazoles. This review provides extensive knowledge on novel synthetic methodologies of biologically active non‐spiro/spiro‐pyrano[2,3‐c]pyrazole derivatives published recently.

中文翻译：

---

吡喃并[2,3-c]吡唑的合成研究进展

通过β-酮酸酯，一水合肼/苯基肼，丙二腈和取代的苯甲醛的两种或多组分缩合一锅法合成吡喃并[2,3-c]吡唑衍生物不仅在合成化学中而且在药物化学中都引起人们的极大兴趣由于吡喃并吡唑类具有巨大的生物学活性，例如抗癌，抗炎，镇痛，抗微生物和酶抑制活性。这篇综述提供了有关最近发表的具有生物活性的非螺/螺-吡喃并[2,3-c]吡唑衍生物的新颖合成方法的广泛知识。