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Genetic analysis of resistance in Mekong striped catfish (Pangasianodon hypophthalmus) to bacillary necrosis caused by Edwardsiella ictaluri
Journal of Fish Diseases ( IF 2.5 ) Pub Date : 2020-11-20 , DOI: 10.1111/jfd.13279
Khoi Dinh Pham 1, 2 , Jørgen Ødegård 1, 3 , Sang Van Nguyen 2 , Hans Magnus Gjøen 1 , Gunnar Klemetsdal 1
Affiliation  

The aim of this study was to analyse four cohabitation challenge‐test experiments with Mekong striped catfish (Pangasianodon hypophthalmus) against the bacterium Edwardsiella ictaluri. The data were genetically analysed per experiment by three models: 1) a cross‐sectional linear model; 2) a cross‐sectional threshold model; and 3) a linear survival model, at both 50% mortality (for models 1 and 2) and at the end of the test (for all three models). In two of the experiments (3 and 4) that were carried out in two replicated tanks, the predicted family effects (sum of sire, dam and common environmental effects) in each tank were correlated with the family survival in the other replicated tank (cross‐validation). The heritability estimates of resistance to E. ictaluri infection were ≤ 0.012 with the survival model, and up to 0.135 – 0.220 (50% survival) and 0.085 and 0.174 (endpoint survival) for the cross‐sectional linear and threshold models, respectively. The challenge test should aim for an endpoint survival that ceases naturally at 50%. Then, genetic analysis should be carried out for survival at the endpoint (reflecting susceptibility) with a simple cross‐sectional linear model.

中文翻译:

湄公河条纹striped鱼对爱德华氏菌引起的细菌坏死的抗性遗传分析

这项研究的目的是分析四个湄公河条纹cat鱼(Eastsiella ictaluri)对湄公河条纹striped鱼(Pangasianodon hypophthalmus)的同居挑战试验。每个实验通过以下三种模型对数据进行遗传分析:1)横截面线性模型;2)横截面阈值模型;和3)线性生存模型,死亡率均为50%(对于模型1和2),并且在测试结束时(对于所有三个模型)。在两个复制罐中进行的两个实验(3和4)中,每个罐中的预测家庭效应(父亲,水坝和常见环境效应的总和)与另一个复制罐中的家庭生存相关(交叉验证)。抗麦芽球菌的遗传力估计生存模型的感染率≤0.012,横截面线性模型和阈值模型的感染率分别为0.135 – 0.220(50%生存率)和0.085和0.174(终点生存率)。挑战测试应针对可自然终止于50%的终点生存。然后,应使用简单的横截面线性模型进行遗传分析,以求终点处的生存(反映敏感性)。
更新日期:2021-01-12
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