The fabrication of biomimetic catalysts as substituents for enzymes is of critical interest in the field due to the problems associated with the extraction, purification, and storage of enzymes in sensing applications. Of these mimetics, hemin/coordination polymer‐based nanocomposites, mainly hemin/metal–organic frameworks (MOF), have been developed for various biosensing applications because of the unique properties of each component, while trying to mimic the normal biological functions of heme within the protein milieu of enzymes. This critical review first discusses the different catalytic functions of heme in the body in the form of enzyme/protein structures. The properties of hemin dimerization are then elucidated with the supposed models of hemin oxidation. After that, the progress in the fabrication of hemin/MOF nanocomposites for the sensing of diverse biological molecules is discussed. Finally, the challenges in developing this type of composites are examined as well as possible proposals for future directions to enhance the sensing performance in this field further.

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血红素/配位聚合物基纳米复合材料的设计和传感应用的最新进展

由于与传感应用中酶的提取、纯化和储存相关的问题，制造仿生催化剂作为酶的取代基在该领域具有重要意义。在这些模拟物中，基于血红素/配位聚合物的纳米复合材料，主要是血红素/金属有机框架 (MOF)，由于每种成分的独特性质，已被开发用于各种生物传感应用，同时试图模拟血红素的正常生物学功能。酶的蛋白质环境。这篇批判性评论首先讨论了血红素在体内以酶/蛋白质结构形式的不同催化功能。然后用血红素氧化的假定模型阐明血红素二聚化的特性。在那之后，讨论了制备用于传感多种生物分子的氯化血红素/MOF 纳米复合材料的进展。最后，研究了开发此类复合材料的挑战以及未来方向的可能建议，以进一步提高该领域的传感性能。