For several years, hyaluronic acid (HyA) and, more recently, polyacrylamide hydrogel (PHyd) have been used to reduce lameness and pain caused by osteoarthritis. However, there is still a lack of scientific evidence of the efficacy of these substances to allow veterinary experts to make decisions about their use in horses. The objective of this study was to evaluate, through a systematic review and network meta-analysis (NMA), the efficacy of HyA, associated or not with other drugs, and PHyd in relieving lameness in horses with osteoarthritis. The searches for primary studies were conducted on four search platforms. The efficacy of HyA and PHyd was estimated through the relative risk difference method. Heterogeneity was observed in the efficacy of HyA, indicating long-term ineffectiveness of this drug when associated or not with anti-inflammatory drugs. In contrast, the results indicate that PHyd is an effective alternative therapy, with a long period of action in reducing lameness in horses with osteoarthritis. This study provides evidence that the application of PHyd and HyA is effective in reducing lameness caused by osteoarthritis in horses at different time periods, where PHyd has a longer time of action.

几年来，透明质酸（HyA）和最近的聚丙烯酰胺水凝胶（PHyd）已被用于减少骨关节炎引起的la行和疼痛。但是，仍然缺乏科学的证据证明这些物质的功效，无法使兽医专家做出有关在马中使用它们的决定。这项研究的目的是通过系统评价和网络荟萃分析（NMA）评估HyA（与其他药物相关或不与其他药物相关联）和PHyd缓解骨关节炎马la腿的功效。初级研究的搜索是在四个搜索平台上进行的。HyA和PHyd的疗效通过相对风险差异法进行评估。在HyA的功效中观察到异质性，表明该药物与消炎药联用或不联用时长期无效。相比之下，结果表明PHyd是一种有效的替代疗法，在减少患有骨关节炎的马的la行中具有长期作用。这项研究提供了证据，表明在不同的时间段，PHyd作用时间较长的情况下，PHyd和HyA的应用可有效减少因骨关节炎引起的la行。