Abstract Using a mouse model of diet-induced obesity in males and females C57BL/6 mice, effects of a yoghurt enriched with proteins on pro-inflammatory cytokine and lipid profiles were assessed. A clear sex-dependent behaviour of the mice was shown; females gained less weight than males independent of the diet. When a high fat diet was implemented with yoghurt, a reduction of cholesterol and triglycerides in liver and blood serum of males, and triglycerides in the liver of females was observed. For male mice fed with yoghurt, a significant reduction of the levels of pro-inflammatory cytokines was detected; in female mice, the anti-inflammatory effect due to yoghurt consumption was observed only to a minor extent. Principal component analysis confirmed that gender or diet was able to group individual animals. A higher variability of data was observed in females compared with males, probably the reason why less significant differences were observed in the former.

中文翻译：

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富含蛋白质的酸奶在饮食诱导肥胖小鼠模型中的性别依赖性影响

摘要 使用雄性和雌性 C57BL/6 小鼠饮食诱导肥胖的小鼠模型，评估富含蛋白质的酸奶对促炎细胞因子和脂质谱的影响。显示了小鼠明显的性别依赖性行为；与饮食无关的女性体重比男性少。当与酸奶一起实施高脂肪饮食时，观察到男性肝脏和血清中的胆固醇和甘油三酯以及女性肝脏中的甘油三酯降低。对于用酸奶喂养的雄性小鼠，检测到促炎细胞因子水平显着降低；在雌性小鼠中，仅在较小程度上观察到因食用酸奶而产生的抗炎作用。主成分分析证实性别或饮食能够将个体动物分组。