Background

The prevalence of arterial hypertension (AHT), a well-known risk factor for cardiovascular disease, has considerably increased over last decades. Non-persistent environmental pollutants (npEPs) are a group of ubiquitous chemicals, widely used in consumer products such as food packaging and cosmetics, which have been identified as endocrine disrupting chemicals and obesogens. The aim of this study was to assess the potential associations of serum levels of three groups of npEPs with the risk of incident AHT.

Methods

Cohort study within a sub-cohort of Granada EPIC-Spain center (n = 670). We quantified serum concentrations of three groups of npEPs, i.e., bisphenol A (BPA), four parabens: methylparaben (MP), ethylparaben (EP), propylparaben (PP) and butylparaben (BP), and two benzophenones: benzophenone 1 (BP1), benzophenone 3 (BP3), in samples collected at recruitment. Statistical analyses were performed by means of Cox Proportional Hazard Models.

Results

Median follow-up time was 23 years. BPA and MP were found in >80% of the study population. Individuals within the 4th PP quartile (0.53–9.24 ng/ml) showed a statistically significant increased risk of AHT (HR = 1.40, p = 0.015). No associations were found for the rest of pollutants.

Conclusions

Overall, we evidenced no associations of most npEPs with AHT risk, with the exception of an increased risk in the highest PP percentiles. Considering the limitations of using one spot serum sample for exposure characterization, further research on the potential contribution of npEPs on the development of AHT risk is warranted.

中文翻译：

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来自EPIC研究的亚人群血清中非持久性环境污染物的水平和发生高血压的风险

背景

在过去的几十年中，众所周知的心血管疾病危险因素动脉高压（AHT）的发病率已大大增加。非持久性环境污染物（npEPs）是一组普遍存在的化学物质，已广泛用于食品包装和化妆品等消费产品中，已被确定为破坏内分泌的化学物质和致肥胖物。这项研究的目的是评估三组npEPs的血清水平与发生AHT风险的潜在关联。

方法

在格拉纳达EPIC-西班牙中心的一个子队列中进行队列研究（n = 670）。我们量化了三组npEPs的血清浓度，即双酚A（BPA），四种对羟基苯甲酸酯：对羟基苯甲酸甲酯（MP），对羟基苯甲酸乙酯（EP），对羟基苯甲酸丙酯（PP）和对羟基苯甲酸丁酯（BP），以及两种二苯甲酮：二苯甲酮1（BP1）招聘时收集的样品中的二苯甲酮3（BP3）。统计分析是通过考克斯比例危害模型进行的。

结果

中位随访时间为23年。在超过80％的研究人群中发现了BPA和MP。在第4 PP四分位数（0.53–9.24 ng / ml）内的个体显示出AHT的统计学显着增加风险（HR = 1.40，p = 0.015）。没有发现其他污染物的关联。

结论

总体而言，我们证明大多数npEP与AHT风险没有关联，除了最高PP百分位数的风险增加外。考虑到使用一个斑点血清样品进行暴露特征分析的局限性，有必要进一步研究npEPs对AHT风险发展的潜在贡献。