The objectives of the study were to determine the dose-dependent effects of active immunization against inhibin α-subunit (AIINHA) on ovarian dynamics, concentrations of progesterone (P₄), pregnancy rate (PR), embryonic and fetal losses (EFL), and prolificacy during the non-breeding season when there was imposing of a progestin-based treatment regimen to induce estrus in Beetal goats. Goats (n = 30) were randomly assigned into following groups: 1) saline (G-CON-0 mg; n = 10), 2) small dose (G-AIINHA-0.5 mg; n = 10), and 3) large dose (G-AIINHA-1 mg; n = 10). The primary administration of inhibin immunogen was administered at Day -48, followed by another administration at Day -20, and subsequently there was induction of estrus using a progestin based treatment regimen that included a single administration of progestin-containing sponge and PGF_2α at Day -8. The sponge was removed, and GnRH was administered at Day -3 followed by breeding (Day 0) at standing estrus. Results indicated mean diameter of the follicles, size of pre-ovulatory follicles and corpora lutea, and post-breeding P₄ concentrations were greater (P < 0.05) in the goat does of the G-AIINHA-0.5 than G-CON-0 group. The PR, and EFL, however, did not differ (P> 0.05) among groups, whereas prolificacy rate was greater (P = 0.04) in goat does of the G-AIINHA-0.5 than G-CON-0 groups. The data from this study indicate G-AIINHA-0.5 is the recommended dose of inhibin immunogen to enhance the reproductive performance during non-breeding season in Beetal goats when estrus is induced using a progestin-based treatment regimen.

该研究的目的是确定针对抑制素 α 亚基 (AIINHA) 的主动免疫对卵巢动力学、孕酮浓度 (P ₄ )、妊娠率 (PR)、胚胎和胎儿丢失(EFL)、在非繁殖季节，当采用基于孕激素的治疗​​方案来诱导 Beetal 山羊发情时，多产。山羊 ( n = 30) 被随机分配到以下组：1) 盐水 (G-CON-0 毫克；n = 10)，2) 小剂量 (G-AIINHA-0.5 毫克；n = 10)，和 3) 大剂量剂量（G-AIINHA-1 毫克；n =10）。抑制素免疫原的主要给药在第 -48 天给药，随后在第 -20 天给药，随后使用基于孕激素的治疗​​方案诱导发情，包括在第 1 天单次给药含孕激素的海绵和 PGF _2α -8. 取出海绵，并在第-3 天施用 GnRH，然后在站立发情期进行繁殖（第 0 天）。结果表明，G-AIINHA-0.5 组山羊的卵泡平均直径、排卵前卵泡和黄体的大小以及繁殖后 P ₄浓度高于G-AIINHA-0.5 组（P < 0.05） . 然而，PR和EFL在各组之间没有差异（P> 0.05），而多产率更高（P = 0.04) G-AIINHA-0.5 组的山羊剂量比 G-CON-0 组高。该研究的数据表明，G-AIINHA-0.5 是推荐剂量的抑制素免疫原，当使用基于孕激素的治疗​​方案诱导发情时，用于提高 Beetal 山羊非繁殖季节的繁殖性能。