Dermatomycoses caused by Candida spp. are increasingly common, however there are few reports in the literature regarding their epidemiology, pathogenesis and antifungal susceptibility of these fungal pathogens. This study aimed to identify, characterize virulence and determine the antifungal susceptibility of Candida species isolated from patients with dermatomycoses. We studied a total of 45 yeast samples isolated from dermal scrapings from patients treated at a public hospital, Bauru, São Paulo, Brazil. After identification, the samples were analyzed for protease activity, phospholipase, biofilm formation and antifungal susceptibility. The most common species was Candida albicans (40%), followed by C. krusei (22.22%), C. parapsilosis complex (22.22%) and C. famata (6.67%). Regarding virulence mechanisms, 57.78% and 28.89% of the samples showed enzymatic activity for protease and phospholipase, respectively. A total of 13.33% of the samples showed secretion of both enzymes. All isolates were biofilm producers, and a higher production was observed in C. tropicalis isolates. Regarding the antifungal susceptibility test, 97.78% of the samples had the highest levels of the minimal inhibitory concentration (MIC) for terbinafine, and one C. krusei sample showed intermediate susceptibility to fluconazole. The correct identification of dermatomycosis-related microorganisms, as well as a better knowledge of their pathogenicity and susceptibility against the antifungals used in the clinic, is extremely important for an efficient preventive and therapeutic action.

由念珠菌属引起的皮肤真菌病。越来越普遍，但是文献中关于这些真菌病原体的流行病学、发病机制和抗真菌敏感性的报道很少。本研究旨在鉴定、表征毒力并确定从皮肤真菌病患者中分离的念珠菌属物种的抗真菌敏感性。我们研究了总共 45 个酵母样本，这些酵母样本是从在巴西圣保罗包鲁的一家公立医院接受治疗的患者的皮肤刮屑中分离出来的。鉴定后，分析样品的蛋白酶活性、磷脂酶、生物膜形成和抗真菌敏感性。最常见的物种是白色念珠菌(40%)，其次是克柔念珠菌(22.22%)，C. parapsilosis complex (22.22%) 和C. famata (6.67%)。关于毒力机制，57.78% 和 28.89% 的样品分别显示蛋白酶和磷脂酶的酶活性。总共 13.33% 的样品显示出两种酶的分泌。所有分离株都是生物膜生产者，在热带念珠菌分离株中观察到更高的产量。在抗真菌药敏试验方面，97.78% 的样品中特比萘芬的最低抑菌浓度 (MIC) 最高，克柔念珠菌 1样品对氟康唑表现出中等敏感性。正确识别与皮肤真菌病相关的微生物，以及更好地了解它们对临床使用的抗真菌药的致病性和敏感性，对于有效的预防和治疗作用极为重要。