Purpose

The study aimed to formulate hydrocolloid dressings incorporated with nano calcium oxide for effective wound healing. Hydrocolloid dressings create an insulated, moist environment in the wound bed for controlling the exudate and promoting autolytic debridement. Calcium ions play an important role in wound response and are considered to be an initial trigger in our immune response to healing, and research has shown that Ca²⁺ in the external medium is essential for wound repair.

Methods

Seventy five parts per million of nano calcium oxide (NCO) obtained by thermal decomposition of calcium nitrate at 450 °C was used in the preparation of hydrocolloid dressings along with varying concentrations of micronized xanthan gum and HPMC. The dressings were evaluated for their surface characteristics, thickness, mechanical properties, folding endurance, pH, viscosity, swelling studies, water vapor transmission, and in vivo wound healing activity.

Results

The average particle size of NCO was found to be 307.8 nm. The SEM (scanning electron microscopy) analysis of the dressing revealed a porous surface and EDX (energy dispersive X-ray spectroscopy) characterization showed intense peaks of calcium and oxygen. The formulated dressings possessed uniform thickness, flexibility, and mechanical strength. The percentage of wound contraction was higher in wounds treated with formulated hydrocolloid dressings in comparison to standard commercial product (DuoDERM® hydrocolloid dressing) and control (untreated) group. The wound healing properties of hydrocolloid dressings were confirmed by histopathological analysis.

Conclusion

Nano calcium incorporated hydrocolloid dressings with enhanced wound healing activity were developed successfully.

中文翻译：

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纳米氧化钙伤口护理用水胶体敷料

目的

该研究旨在配制掺有纳米氧化钙的水胶体敷料，以实现有效的伤口愈合。水胶体敷料可在伤口床中创造一个绝缘，潮湿的环境，以控制渗出液并促进自溶性清创术。钙离子在伤口反应中起着重要作用，被认为是我们对愈合的免疫反应的最初触发因素，研究表明，外部介质中的Ca ²⁺对于伤口修复至关重要。

方法

通过在450°C下热分解硝酸钙获得的百万分之75的纳米氧化钙（NCO）与不同浓度的微粉化黄原胶和HPMC一起用于制备水胶体敷料。评估敷料的表面特性，厚度，机械性能，耐折性，pH，粘度，溶胀研究，水蒸气透过率和体内伤口愈合活性。

结果

发现NCO的平均粒径为307.8nm。敷料的SEM（扫描电子显微镜）分析显示出多孔表面，EDX（能量分散X射线能谱）表征显示出钙和氧的强烈峰。配制的敷料具有均匀的厚度，柔韧性和机械强度。与标准的商业产品（DuoDERM®水胶体敷料）和对照组（未处理）相比，使用配制的水胶体敷料处理的伤口的伤口收缩百分比更高。通过组织病理学分析证实了水胶体敷料的伤口愈合特性。

结论

成功开发出具有增强的伤口愈合活性的纳米钙结合水胶体敷料。