The current global fight against coronavirus disease (COVID-19) to flatten the transmission curve is put forth by the World Health Organization (WHO) as there is no immediate diagnosis or cure for COVID-19 so far. In order to stop the spread, researchers worldwide are working around the clock aiming to develop reliable tools for early diagnosis of severe acute respiratory syndrome (SARS-CoV-2) understanding the infection path and mechanisms. Currently, nucleic acid-based molecular diagnosis (real-time reverse transcription polymerase chain reaction (RT-PCR) test) is considered the gold standard for early diagnosis of SARS-CoV-2. Antibody-based serology detection is ineffective for the purpose of early diagnosis, but a potential tool for serosurveys, providing people with immune certificates for clearance from COVID-19 infection. Meanwhile, there are various blooming methods developed these days. In this review, we summarise different types of coronavirus discovered which can be transmitted between human beings. Methods used for diagnosis of the discovered human coronavirus (SARS, MERS, COVID-19) including nucleic acid detection, gene sequencing, antibody detection, antigen detection, and clinical diagnosis are presented. Their merits, demerits and prospects are discussed which can help the researchers to develop new generation of advanced diagnostic tools for accurate and effective control of human coronavirus transmission in the communities and hospitals.

世界卫生组织 (WHO) 提出了当前全球抗击冠状病毒病 (COVID-19) 以拉平传播曲线的斗争，因为目前还没有针对 COVID-19 的直接诊断或治愈方法。为了阻止这种传播，世界各地的研究人员正在昼夜不停地工作，旨在开发可靠的工具，用于早期诊断严重急性呼吸系统综合症 (SARS-CoV-2)，了解感染路径和机制。目前，基于核酸的分子诊断（实时逆转录聚合酶链反应（RT-PCR）检测）被认为是早期诊断SARS-CoV-2的金标准。基于抗体的血清学检测对于早期诊断无效，但却是一种潜在的血清调查工具，可为人们提供免疫证明，以清除 COVID-19 感染。同时，这些天开发了各种开花方法。在这篇综述中，我们总结了发现的可以在人与人之间传播的不同类型的冠状病毒。介绍了用于诊断发现的人类冠状病毒（SARS、MERS、COVID-19）的方法，包括核酸检测、基因测序、抗体检测、抗原检测和临床诊断。讨论了它们的优缺点和前景，可以帮助研究人员开发新一代先进的诊断工具，以准确有效地控制人类冠状病毒在社区和医院的传播。介绍了用于诊断发现的人类冠状病毒（SARS、MERS、COVID-19）的方法，包括核酸检测、基因测序、抗体检测、抗原检测和临床诊断。讨论了它们的优缺点和前景，可以帮助研究人员开发新一代先进的诊断工具，以准确有效地控制人类冠状病毒在社区和医院的传播。介绍了用于诊断发现的人类冠状病毒（SARS、MERS、COVID-19）的方法，包括核酸检测、基因测序、抗体检测、抗原检测和临床诊断。讨论了它们的优缺点和前景，可以帮助研究人员开发新一代先进的诊断工具，以准确有效地控制人类冠状病毒在社区和医院的传播。